Reno's journey began at the Punchline Comedy Club in Atlanta, GA where he tended bar to supplement his day job. One night he found himself on stage during the weekly open mic night. His unique outlook on life - mixed with a six-pack - was instantly popular and provided a platform to launch a career as a comedian.

Reno has built a reputation by selling out comedy clubs and colleges nationwide. In 2004 he joined Larry The Cable Guy on the hugely successful Tour of America. Following the success of that tour, in 2005 Reno taped his own Comedy Central Presents half-hour special. He can currently be heard on Sirius Satellite Radio show Chewing the Fat that he cohosts with fellow comedian Leanne Morgan. Reno is also the national spokesperson for A Soldier’s Child, an organization that serves the children of fallen military personnel.